Skip Navigation


Carcinogenesis Advance Access originally published online on March 28, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
24/6/1015    most recent
bgg041v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (30)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Yamada, Y.
Right arrow Articles by Mori, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamada, Y.
Right arrow Articles by Mori, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol. 24, No. 6, 1015-1019, June 2003
© 2003 Oxford University Press

COMMENTARY

Pre-cancerous lesions for colorectal cancers in rodents: a new concept

Yasuhiro Yamada and Hideki Mori1

Department of Pathology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan

1 To whom correspondence should be addressed Email: hidmori{at}cc.gifu-u.ac.jp

It is widely believed that colorectal carcinogenesis is a representative multi-step tumorigenesis with events of genetic alterations. Aberrant crypt foci (ACF) recognized on the surface of cancer-predisposed colons of rodents have been regarded as early-appearing pre-neoplastic lesions. However, it is not clear if such lesions are truly pre-cancerous lesions for colorectal cancers in rodents. Recently, ß-catenin-accumulated crypts (BCAC) were identified in colonic mucosa at the early stages of colon carcinogenesis. Accumulating evidence indicates that they are independent small dysplastic lesions of ACF. Here we discuss the importance of BCAC as pre-cancerous lesions in colon carcinogenesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M. Shimizu, Y. Shirakami, J. Iwasa, M. Shiraki, Y. Yasuda, K. Hata, Y. Hirose, H. Tsurumi, T. Tanaka, and H. Moriwaki
Supplementation with Branched-chain Amino Acids Inhibits Azoxymethane-induced Colonic Preneoplastic Lesions in Male C57BL/KsJ-db/db Mice
Clin. Cancer Res., May 1, 2009; 15(9): 3068 - 3075.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
M. Shimizu, Y. Shirakami, H. Sakai, S. Adachi, K. Hata, Y. Hirose, H. Tsurumi, T. Tanaka, and H. Moriwaki
(-)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice
Cancer Prevention Research, September 1, 2008; 1(4): 298 - 304.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
T. Oyama, Y. Yamada, K. Hata, H. Tomita, A. Hirata, H. Sheng, A. Hara, H. Aoki, T. Kunisada, S. Yamashita, et al.
Further upregulation of {beta}-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice
Carcinogenesis, March 1, 2008; 29(3): 666 - 672.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. M. Ramocki, H. R. Wilkins, S. T. Magness, J. G. Simmons, B. P. Scull, G. H. Lee, K. K. McNaughton, and P. K. Lund
Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apcmin/+ Tumors, and Regulates Sox9
Endocrinology, January 1, 2008; 149(1): 261 - 267.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
O. K. Glebov, L. M. Rodriguez, P. Soballe, J. DeNobile, J. Cliatt, K. Nakahara, and I. R. Kirsch
Gene Expression Patterns Distinguish Colonoscopically Isolated Human Aberrant Crypt Foci from Normal Colonic Mucosa.
Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2253 - 2262.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. A. Narayanan, N. K. Narayanan, D. Desai, B. Pittman, and B. S. Reddy
Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and {beta}-catenin pathways in colon cancer cells
Carcinogenesis, December 1, 2004; 25(12): 2443 - 2449.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. Fujiwara, M. Ochiai, T. Ohta, M. Ohki, H. Aburatani, M. Nagao, T. Sugimura, and H. Nakagama
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Carcinogenesis, August 1, 2004; 25(8): 1495 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. J. Kelloff, R. L. Schilsky, D. S. Alberts, R. W. Day, K. Z. Guyton, H. L. Pearce, J. C. Peck, R. Phillips, and C. C. Sigman
Colorectal Adenomas: A Prototype for the Use of Surrogate End Points in the Development of Cancer Prevention Drugs
Clin. Cancer Res., June 1, 2004; 10(11): 3908 - 3918.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. P. Femia, P. Dolara, and G. Caderni
Mucin-depleted foci (MDF) in the colon of rats treated with azoxymethane (AOM) are useful biomarkers for colon carcinogenesis
Carcinogenesis, February 1, 2004; 25(2): 277 - 281.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.