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Carcinogenesis Advance Access originally published online on March 4, 2004
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Carcinogenesis, Vol. 25, No. 7, 1137-1147, July 2004
Carcinogenesis vol.25 no.7 © Oxford University Press 2004; all rights reserved.

ARTICLE

Akt mediates an angiogenic switch in transformed keratinocytes

Carmen Segrelles, Sergio Ruiz, Mirentxu Santos, Jesús Martínez-Palacio, M. Fernanda Lara and Jesús M. Paramio1

Department of Cell and Molecular Biology, CIEMAT, Av. Complutense 22, E-28040 Madrid, Spain

1 To whom correspondence should be addressed Email: jesusm.paramio{at}ciemat.es

Akt signaling is involved in tumorigenesis via a number of different mechanisms that result in increased proliferation and decreased apoptosis. Previous data have demonstrated that Akt-mediated signaling is functionally involved in keratinocyte transformation. This work investigates the involvement of angiogenesis as a mediator of tumorigenesis in Akt-transformed keratinocytes. Tumors produced by subcutaneous injection of the latter showed increased angiogenic profiles associated with increased vascular endothelial growth factor (VEGF) protein levels. However, in contrast to v-rasHa-transformed keratinocytes, VEGF mRNA levels were not increased. The induction of VEGF protein by Akt is associated with increased phosphorylation and thus activation of p70S6K and eIF4E-binding protein 1, leading to increased VEGF translation. In addition, we observed increased metaloproteinases 2 and 9 expression, but not thrombospondin 1, in tumors derived from Akt-transformed keratinocytes. Collectively, these results demonstrate that Akt is an important mediator of angiogenesis in malignant keratinocytes through a post-transcriptional mechanism.


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