Carcinogenesis Advance Access originally published online on April 29, 2004
Carcinogenesis 2004 25(9):1587-1592; doi:10.1093/carcin/bgh171
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Carcinogenesis vol.25 no.9 © Oxford University Press 2004; all rights reserved.
ARTICLE |
PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells
1 A&G Pharmaceutical Inc., Columbia, Maryland, 2 Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland and 3 Program in Oncology, Greenebaum Cancer Center of the University of Maryland, Baltimore, Maryland, USA
4 To whom correspondence should be addressed Email: gserrero{at}agrx.net
Metastasis is a multi-step process involved in the progression of breast cancer to a disease with poor prognosis. Growth factor and/or growth factor receptor over- expression have been reported to play an important role in this process. The 88 kDa glycoprotein PC cell-derived growth factor (PCDGF/GP88), also known as progranulin, has been shown to play a major role in breast tumorigenesis by stimulating proliferation, mediating survival and conferring resistance to tamoxifen. In the present paper, the metastatic potential of PCDGF/GP88 was examined in breast cancer. Using MCF-7 cells, we showed that PCDGF/GP88 over-expression stimulated anchorage-independent cell growth and accelerated cell migration through matrigel. Similar results were obtained with MCF-7 cells treated exogenously with PCDGF/GP88. Furthermore, gelatin zymograph and immunoblot revealed that matrix metalloprotease-9 was up-regulated by PCDGF/GP88. PCDGF/GP88 stimulated VEGF expression in MCF-7 cells. These results suggest that PCDGF/GP88 could act to promote metastasis and angiogenesis in human breast cancer cells in addition to stimulating their proliferation and survival.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Gliebus, A. Rosso, and C. F. Lippa Progranulin and {beta}-Amyloid Distribution: A Case Report of the Brain From Preclinical PS-1 Mutation Carrier American Journal of Alzheimer's Disease and Other Dementias, December 1, 2009; 24(6): 456 - 460. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Lovat, A. Bitto, S.-Q. Xu, M. Fassan, S. Goldoni, D. Metalli, V. Wubah, P. McCue, G. Serrero, L. G. Gomella, et al. Proepithelin is an autocrine growth factor for bladder cancer Carcinogenesis, May 1, 2009; 30(5): 861 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Monami, V. Emiliozzi, A. Bitto, F. Lovat, S.-Q. Xu, S. Goldoni, M. Fassan, G. Serrero, L. G. Gomella, R. Baffa, et al. Proepithelin Regulates Prostate Cancer Cell Biology by Promoting Cell Growth, Migration, and Anchorage-Independent Growth Am. J. Pathol., March 1, 2009; 174(3): 1037 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Desmarais, M. Cao, A. Bateman, and B. D Murphy Spatiotemporal expression pattern of progranulin in embryo implantation and placenta formation suggests a role in cell proliferation, remodeling, and angiogenesis Reproduction, August 1, 2008; 136(2): 247 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sleegers, N. Brouwers, S. Maurer-Stroh, M. A. van Es, P. V. Damme, P.W.J. van Vught, J. van der Zee, S. Serneels, T. D. Pooter, M. Van den Broeck, et al. Progranulin genetic variability contributes to amyotrophic lateral sclerosis Neurology, July 22, 2008; 71(4): 253 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Woolley, M. R. Wilson, E. Hung, M.-L. Gorno-Tempini, B. L. Miller, and J. Shim Frontotemporal Dementia and Mania Am J Psychiatry, December 1, 2007; 164(12): 1811 - 1816. [Full Text] [PDF]
|
|
|
|
|
|
D. Irwin, C. F. Lippa, and J.M. Swearer Cognition and Amyotrophic Lateral Sclerosis (ALS) American Journal of Alzheimer's Disease and Other Dementias, September 1, 2007; 22(4): 300 - 312. [Abstract] [PDF]
|
|
|
|
 |
|
 P.-S. Chen, M.-Y. Wang, S.-N. Wu, J.-L. Su, C.-C. Hong, S.-E. Chuang, M.-W. Chen, K.-T. Hua, Y.-L. Wu, S.-T. Cha, et al. CTGF enhances the motility of breast cancer cells via an integrin-{alpha}vbeta3-ERK1/2-dependent S100A4-upregulated pathway J. Cell Sci., June 15, 2007; 120(12): 2053 - 2065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Snowden, S. M. Pickering-Brown, I. R. Mackenzie, A. M. T. Richardson, A. Varma, D. Neary, and D. M. A. Mann Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia Brain, November 1, 2006; 129(11): 3091 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Talbot and O. Ansorge Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease Hum. Mol. Genet., October 15, 2006; 15(suppl_2): R182 - R187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Monami, E. M. Gonzalez, M. Hellman, L. G. Gomella, R. Baffa, R. V. Iozzo, and A. Morrione Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex. Cancer Res., July 15, 2006; 66(14): 7103 - 7110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. E. Kim and G. Serrero PC Cell-Derived Growth Factor Stimulates Proliferation and Confers Trastuzumab Resistance to Her-2-Overexpressing Breast Cancer Cells. Clin. Cancer Res., July 15, 2006; 12(14): 4192 - 4199. [Abstract] [Full Text] [PDF]
|
|