Skip Navigation


Carcinogenesis Advance Access originally published online on April 29, 2004
Carcinogenesis 2004 25(9):1619-1628; doi:10.1093/carcin/bgh177
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
25/9/1619    most recent
bgh177v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brink, M.
Right arrow Articles by van den Brandt, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brink, M.
Right arrow Articles by van den Brandt, P. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis vol.25 no.9 © Oxford University Press 2004; all rights reserved.

ARTICLE

Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study

Mirian Brink1, Matty P. Weijenberg1,5, Anton F. P. M. de Goeij2, Leo J. Schouten1, Femke D. H. Koedijk1, Guido M. J. M. Roemen3, Marjolein H. F. M. Lentjes3, Adriaan P. de Bruïne2, R.Alexandra Goldbohm4 and Piet A. van den Brandt1

1 Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, 2 Research Institute Growth and Development (GROW), Department of Pathology, Maastricht University, 3 NUTRIM, Department of Pathology, Maastricht University, and 4 TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, The Netherlands

5 To whom correspondence should be addressed Email: mp.weijenberg{at}epid.unimaas.nl

Associations between dietary intake of various fats and specific K-ras mutations in colorectal cancer (CRC) were investigated within the framework of The Netherlands Cohort Study on diet and cancer (NLCS). After 7.3 years of follow-up and with exclusion of the first 2.3 years, 448 colon and 160 rectal cancer patients and 2948 subcohort members (55–69 years at baseline) were available for data-analyses. Mutation analysis of the K-ras gene was performed on all archival colon and rectal adenocarcinoma specimens. Case-cohort analyses were used to compute adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) for colon and rectal cancer cases and for K-ras mutation subgroups. The intake of total, saturated and monounsaturated fat was not significantly associated with colon or rectal cancer. High intake of dietary polyunsaturated fat and, specifically, linoleic acid is associated with an increased risk of mutated K-ras colon tumours. The RRs for 1 SD of increase of polyunsaturated fat and linoleic acid were 1.21 (95% CI 1.05–1.41) and 1.22 (95% CI 1.05–1.42), respectively, and similar associations were observed for both G > A transitions and G > T or G > C transversions in the colon. In contrast, no significant associations were observed with rectal cancer risk, overall nor with specific K-ras mutation status. A high intake of polyunsaturated fat, in particular linoleic acid, may be an important dietary risk factor for K-ras mutated colon tumours, possibly by generating G > A transitions or G > T or G > C transversions in the K-ras oncogene.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
Y. S. Kim and J. A. Milner
Dietary Modulation of Colon Cancer Risk
J. Nutr., November 1, 2007; 137(11): 2576S - 2579S.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.