Skip Navigation


Carcinogenesis Advance Access originally published online on April 8, 2004
Carcinogenesis 2004 25(9):1689-1694; doi:10.1093/carcin/bgh166
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
25/9/1689    most recent
bgh166v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (31)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Yamane, A.
Right arrow Articles by Yokota, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamane, A.
Right arrow Articles by Yokota, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis vol.25 no.9 © Oxford University Press 2004; all rights reserved.

ARTICLE

Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo

Arito Yamane1,4, Takashi Kohno1, Kohei Ito1, Noriaki Sunaga1, Kazunori Aoki3, Kimio Yoshimura2, Hirokazu Murakami5, Yoshihisa Nojima4 and Jun Yokota1,6

1 Biology Division, 2 Genetics Division and 3 Section for Studies on Host-immune Response, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, 4 Department of Medicine and Clinical Science and 5 School of Health Sciences, Faculty of Medicine, School of Medicine, Gunma University, 39-15 Showa-machi 3-chome, Maebashi 371-8511, Japan

6 To whom correspondence should be addressed Email: jyokota{at}gan2.ncc.go.jp

OGG1 protein has an ability to suppress mutagenesis induced by 8-hydroxyguanine (8OHG), an oxidatively damaged promutagenic base. Here, the mutation suppressive ability was compared between two common polymorphic OGG1 proteins, OGG1-Ser326 and OGG1-Cys326, using a supF forward mutation assay employing an 8OHG-containing plasmid. Polymorphic OGG1 proteins were exogenously expressed by adenoviral transduction in H1299 human lung cancer cells, in which endogenous OGG1 protein was undetectable by western blot analysis. Mutations by 8OHG were more efficiently suppressed in OGG1-Ser326 transduced cells than OGG1-Cys326 transduced cells. The results indicated that OGG1-Cys326 has a lower ability to prevent mutagenesis by 8OHG than OGG1-Ser326 in vivo in human cells; supporting the results of recent association studies that OGG1-Cys326 is a risk allele for several types of human cancers.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int J EpidemiolHome page
G. Capella, G. Pera, N. Sala, A. Agudo, F. Rico, G. Del Giudicce, M. Plebani, D. Palli, H. Boeing, H B. Bueno-de-Mesquita, et al.
DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study
Int. J. Epidemiol., December 1, 2008; 37(6): 1316 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H. Li, X. Hao, W. Zhang, Q. Wei, and K. Chen
The hOGG1 Ser326Cys Polymorphism and Lung Cancer Risk: A Meta-analysis
Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1739 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
K. Arizono, Y. Osada, and Y. Kuroda
DNA Repair Gene hOGG1 Codon 326 and XRCC1 Codon 399 Polymorphisms and Bladder Cancer Risk in a Japanese Population
Jpn. J. Clin. Oncol., March 1, 2008; 38(3): 186 - 191.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
R. A. Mateuca, M. Roelants, G. Iarmarcovai, P. V. Aka, L. Godderis, A. Tremp, S. Bonassi, M. Fenech, J.-L. Berge-Lefranc, and M. Kirsch-Volders
hOGG1326, XRCC1399 and XRCC3241 polymorphisms influence micronucleus frequencies in human lymphocytes in vivo
Mutagenesis, January 1, 2008; 23(1): 35 - 41.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. Vodicka, R. Stetina, V. Polakova, E. Tulupova, A. Naccarati, L. Vodickova, R. Kumar, M. Hanova, B. Pardini, J. Slyskova, et al.
Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects
Carcinogenesis, March 1, 2007; 28(3): 657 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Paz-Elizur, R. Ben-Yosef, D. Elinger, A. Vexler, M. Krupsky, A. Berrebi, A. Shani, E. Schechtman, L. Freedman, and Z. Livneh
Reduced Repair of the Oxidative 8-Oxoguanine DNA Damage and Risk of Head and Neck Cancer
Cancer Res., December 15, 2006; 66(24): 11683 - 11689.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. Moreno, F. Gemignani, S. Landi, L. Gioia-Patricola, A. Chabrier, I. Blanco, S. Gonzalez, E. Guino, G. Capella, F. Canzian, et al.
Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.
Clin. Cancer Res., April 1, 2006; 12(7): 2101 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. W. Hill and M. K. Evans
Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase
Nucleic Acids Res., March 20, 2006; 34(5): 1620 - 1632.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Zienolddiny, D. Campa, H. Lind, D. Ryberg, V. Skaug, L. Stangeland, D. H. Phillips, F. Canzian, and A. Haugen
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
Carcinogenesis, March 1, 2006; 27(3): 560 - 567.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-K. Youn, S.-H. Kim, D. Y. Lee, S. H. Song, I.-Y. Chang, J.-W. Hyun, M.-H. Chung, and H. J. You
Cadmium Down-regulates Human OGG1 through Suppression of Sp1 Activity
J. Biol. Chem., July 1, 2005; 280(26): 25185 - 25195.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L. Luna, V. Rolseth, G. A. Hildrestrand, M. Otterlei, F. Dantzer, M. Bjoras, and E. Seeberg
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant
Nucleic Acids Res., March 30, 2005; 33(6): 1813 - 1824.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.