Skip Navigation


Carcinogenesis Advance Access originally published online on July 28, 2005
Carcinogenesis 2005 26(12):2207-2212; doi:10.1093/carcin/bgi191
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
26/12/2207    most recent
bgi191v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wenzlaff, A.S.
Right arrow Articles by Schwartz, A.G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wenzlaff, A.S.
Right arrow Articles by Schwartz, A.G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis Vol.26 no.12 © Oxford University Press 2005; all rights reserved.

CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study

A.S. Wenzlaff 1, *, M.L. Cote 1, 2, C.H. Bock 1, 2, S.J. Land 1, 3, 4, S.K. Santer 1, D.R. Schwartz 5 and A.G. Schwartz 1, 2

1 Population Studies and Prevention Program, 2 Department of Internal Medicine, 3 Center for Molecular Medicine and Genetics, 4 Molecular Biology and Human Genetics Program and 5 Proteases and Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA

* To whom correspondence and reprint requests should be addressed. Tel: +1 313 833 0715 ext. 2484; Fax: +1 313 831 7806; Email: wenzlaff{at}med.wayne.edu

The cytochrome P450 (CYP) superfamily of enzymes catalyse one of the first steps in the metabolism of carcinogens such as polycyclic aromatic hydrocarbons, nitroaromatics and arylamines. Polymorphisms within the CYP1A1 gene have been shown to be associated with lung cancer risk, predominantly among Asian populations. Despite functional evidence of a possible role of CYP1B1 in lung cancer susceptibility, only a few studies have evaluated polymorphisms in this gene in relation to lung cancer susceptibility. This population-based study evaluates polymorphisms in both of these CYP genes within never smokers, most of whom had environmental tobacco smoke (ETS) exposure. Cases (n = 160) were identified through the metropolitan Detroit Surveillance, Epidemiology and End Results program, and age, sex and race-matched population-based controls (n = 181) were identified using random digit dialing. Neither CYP1A1 MspI nor CYP1A1 Ile462Val was associated with lung cancer susceptibility among Caucasians or African-Americans. Among Caucasians, however, CYP1B1 Leu432Val was significantly associated with lung cancer susceptibility odds ratio (OR) for at least one valine allele = 2.87 [95% confidence interval (CI) 1.63–5.07]. Combinations of this Phase I enzyme polymorphism along with selected Phase II enzyme polymorphisms (GSTM1 null, GSTP1 Ile105Val and NQO1 C609T) were evaluated. The combination of CYP1B1 Leu432Val and NQO1 C609T appeared to be associated with the highest risk of lung cancer (OR = 4.14, 95% CI 1.60–10.74), although no combinations differed significantly from the risk associated with CYP1B1 Leu432Val alone. When individuals were stratified by household ETS exposure (yes/no), CYP1B1 Leu432Val alone and in combination with Phase II enzyme polymorphisms was more strongly associated with increased lung cancer susceptibility among those with at least some household ETS exposure. Additional studies will be required to further validate these findings among never smokers and to evaluate the effects of this polymorphism among smoking populations as well.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
S. Helmig, B. Hadzaad, J. Dohrel, and J. Schneider
Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
Drug Metab. Dispos., July 1, 2009; 37(7): 1490 - 1495.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. L. Cote, W. Yoo, A. S. Wenzlaff, G. M. Prysak, S. K. Santer, G. B. Claeys, A. L. Van Dyke, S. J. Land, and A. G. Schwartz
Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
Carcinogenesis, April 1, 2009; 30(4): 626 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. C. Aldrich, S. Selvin, H. M. Hansen, L. F. Barcellos, M. R. Wrensch, J. D. Sison, K. T. Kelsey, P. A. Buffler, C. P. Quesenberry Jr., M. F. Seldin, et al.
CYP1A1/2 Haplotypes and Lung Cancer and Assessment of Confounding by Population Stratification
Cancer Res., March 15, 2009; 69(6): 2340 - 2348.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
D. J. Castro, W. M. Baird, C. B. Pereira, J. Giovanini, C. V. Lohr, K. A. Fischer, Z. Yu, F. J. Gonzalez, S. K. Krueger, and D. E. Williams
Fetal Mouse Cyp1b1 and Transplacental Carcinogenesis from Maternal Exposure to Dibenzo(a,l)pyrene
Cancer Prevention Research, July 1, 2008; 1(2): 128 - 134.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
C. Carlsten, G. S. Sagoo, A. J. Frodsham, W. Burke, and J. P. T. Higgins
Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis
Am. J. Epidemiol., April 1, 2008; 167(7): 759 - 774.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K.-A. Yoon, S. Park, B. Hwangbo, H. D. Shin, H. S. Cheong, H.-R. Shin, and J. S. Lee
Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung cancer
Carcinogenesis, September 1, 2007; 28(9): 1971 - 1977.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Kury, B. Buecher, S. Robiou-du-Pont, C. Scoul, V. Sebille, H. Colman, C. Le Houerou, T. Le Neel, J. Bourdon, R. Faroux, et al.
Combinations of Cytochrome P450 Gene Polymorphisms Enhancing the Risk for Sporadic Colorectal Cancer Related to Red Meat Consumption
Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1460 - 1467.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. A. Wakelee, E. T. Chang, S. L. Gomez, T. H. Keegan, D. Feskanich, C. A. Clarke, L. Holmberg, L. C. Yong, L. N. Kolonel, M. K. Gould, et al.
Lung Cancer Incidence in Never Smokers
J. Clin. Oncol., February 10, 2007; 25(5): 472 - 478.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K.-A. Yoon, B. Hwangbo, I.-J. Kim, S. Park, H. S. Kim, H. J. Kee, J. E. Lee, Y. K. Jang, J.-G. Park, and J. S. Lee
Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer
Carcinogenesis, November 1, 2006; 27(11): 2217 - 2222.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. S. Hecht, S. G. Carmella, A. Yoder, M. Chen, Z.-z. Li, C. Le, R. Dayton, J. Jensen, and D. K. Hatsukami
Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers.
Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1805 - 1811.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
L.-R. Zhu, P. E. Thomas, G. Lu, K. R. Reuhl, G.-Y. Yang, L.-D. Wang, S.-L. Wang, C. S. Yang, X.-Y. He, and J.-Y. Hong
CYP2A13 in Human Respiratory Tissues and Lung Cancers: An Immunohistochemical Study with A New Peptide-Specific Antibody
Drug Metab. Dispos., October 1, 2006; 34(10): 1672 - 1676.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.