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Carcinogenesis Advance Access originally published online on October 21, 2004
Carcinogenesis 2005 26(2):281-291; doi:10.1093/carcin/bgh312
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Carcinogenesis vol.26 no.2 © Oxford University Press 2005; all rights reserved.

ARTICLE

Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells

Jian Ma1, Jie Zhou1, Songqing Fan1, Lili Wang1, Xiaoling Li1, Qun Yan2, Ming Zhou1, Huaying Liu1, Qiuhong Zhang1, Houde Zhou1, Kai Gan1, Zheng Li1, Cong Peng1, Wei Xiong1, Chen Tan1, Shourong Shen3, Jianbo Yang1, Jiang Li1 and Guiyuan Li1,4

1 Cancer Research Institute, 2 Xiang-Ya Hospital and 3 The Third Xiang-Ya Hospital of Central South University Xiang-Ya School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan, 410078, China

4 To whom correspondence should be addressed Email: ligy{at}xysm.net

The epidermal growth factor (EGF)-like domain is involved in receptor–ligand interactions, extracellular matrix formation, cell adhesion and chemotaxis. Nasopharyngeal carcinoma associated gene 6 (NGX6) is a novel EGF-like domain-containing gene located at the high frequent loss of heterozygosity (LOH) region 9p21-22 associated with nasopharyngeal carcinoma (NPC). It is down-regulated in NPC and its over-expression can delay the cell cycle G0–G1 progression in NPC cells. In the present study, in situ hybridization analysis, using NPC tissue microarrays, showed that loss of NGX6 expression was associated with NPC lymph node metastasis. The Tet-on gene expression system and cDNA array techniques were used to profile the potential targets of NGX6. We found that NGX6 can influence the expression of some cell adhesion molecules in NPC cells. NGX6 can associate with ezrin, a linkage between the cell membrane and cytoskeleton. The NGX6 protein was expressed on the cell surface as a glycoprotein. Ectopic induction of NGX6 can impair NPC cell migration and invasive ability as well as improve cell adhesion and gap junctional intercellular communication, and can suppress tumor formation in vivo. The data revealed that NGX6 plays a role in cell adhesion modulation in NPC cells.


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 Acta Biochim Biophys SinHome page
Y. Peng, H. Li, M. Wu, X. Wang, S. Fan, F. Liu, B. Xiang, Q. Guo, X. Tang, and S. Shen
NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer
Acta Biochim Biophys Sin, June 1, 2009; 41(6): 504 - 514.
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