Carcinogenesis Advance Access originally published online on November 18, 2004
Carcinogenesis 2005 26(2):449-457; doi:10.1093/carcin/bgh336
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Carcinogenesis vol.26 no.2 © Oxford University Press 2005; all rights reserved.
ARTICLE |
Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption
1 Department of Toxicology Pathology and Genetics, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 2 Department of Pathology, Josephine Nefkens Institute, Erasmus University Rotterdam, Rotterdam, The Netherlands and 3 Division of Human Nutrition, Wageningen University and Research Centre, Agrotechnion, Bomenweg 2 (bode 62), 6703 HD Wageningen, The Netherlands
4 To whom correspondence should be addressed Email: ellen.kampman{at}wur.nl
Associations between polymorphisms in genes (SNPs) involved in the arachidonic acid (AA) pathway and colorectal adenomas have been investigated in a Dutch case control study including 384 cases and 403 polyp-free controls. Twenty-one polymorphisms in seven candidate genes were studied and a potential modifying effect of fish consumption was considered. A protective effect on colorectal adenomas was found for the CT genotype of SNP H477H in PPAR
and the GC genotype of SNP V102V in COX-2 (OR 0.63, 95% CI 0.45–0.89 and OR 0.65, 95% CI 0.46–0.92, respectively) compared with the homozygous major genotypes. An increase in adenoma risk was observed for the TC genotype of SNP c.2242T
C in COX-2 (OR 1.47, 95% CI 1.07–2.00) compared with the TT genotype. Analysis with estimated haplotypes confirmed these associations and revealed three additional associations with COX-2, sPLA2 and 15LOX haplotypes. Fish consumption modified the associations with COX-2 and PPAR
genotypes. For SNP c.-789CT in PPAR the major genotype showed a decrease in adenoma risk for those in the highest tertile of fish consumption (T3), as compared with the lowest tertile (T1) (OR 0.65, 95% CI 0.41–1.02). Protective effects were also observed for SNPs V102V and c.2242TC in COX-2 and high fish intake. The interaction between fish consumption and c.2242TC was statistically significant, with an OR for the TT genotype and high fish consumption of 0.52 (95% CI 0.27–1.01) as compared with low fish intake. These results indicate that SNPs in genes involved in the AA pathway are associated with colorectal adenoma risk. Some of these associations are modified by fish consumption.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. W. Fetterman Jr. and M. M. Zdanowicz Therapeutic potential of n-3 polyunsaturated fatty acids in disease Am. J. Health Syst. Pharm., July 1, 2009; 66(13): 1169 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Poole, J. Bigler, J. Whitton, J. G. Sibert, R. J. Kulmacz, J. D. Potter, and C. M. Ulrich Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps Carcinogenesis, June 1, 2007; 28(6): 1259 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Chapkin, L. A. Davidson, L. Ly, B. R. Weeks, J. R. Lupton, and D. N. McMurray Immunomodulatory Effects of (n-3) Fatty Acids: Putative Link to Inflammation and Colon Cancer J. Nutr., January 1, 2007; 137(1): 200S - 204S. [Abstract] [Full Text] [PDF]
|
|