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Carcinogenesis Advance Access originally published online on February 24, 2005
Carcinogenesis 2005 26(5):908-915; doi:10.1093/carcin/bgi034
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Carcinogenesis vol.26 no.5 © Oxford University Press 2005; all rights reserved.

Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies

Isabella T. Tai *, Meiru Dai 1 and Lan Bo Chen 1

Division of Gastroenterology, University of British Columbia; Genome Sciences Centre, B.C. Cancer Agency, Vancouver, Canada and 1 Department of Cancer Biology, Dana Farber Cancer Institute, Boston, USA

* To whom correspondence should be addressed at: University of British Columbia, Division of Gastroenterology, 100-2647 Willow Street, Vancouver, BC, V5Z 3P1 Canada. Tel: +1 604 875 5039; Fax: +1 604 875 5447; Email: itai{at}bcgsc.ca

Several factors have been shown to promote the growth of colorectal cancers. Here, we provide evidence that periostin, a protein with structural and sequence homology with a TGF-ß-inducible gene, ßig-h3, is upregulated in colorectal cancers and their liver metastasis, and it may play a role in promoting growth in these tumors. In vitro studies reveal that periostin promotes growth and cell proliferation in colorectal cancers and that this effect can be abrogated with antibodies to periostin. Furthermore, exposure of colorectal cancer cells to anti-periostin antibodies activates apoptosis and potentiates the effects of 5-fluorouracil chemotherapy. The results demonstrate the growth-promoting properties of periostin, and a possible role of targeting this protein as a therapeutic option in colorectal cancers.


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