Skip Navigation


Carcinogenesis Advance Access originally published online on October 21, 2004
Carcinogenesis 2005 26(7):1170-1181; doi:10.1093/carcin/bgh317
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
26/7/1170    most recent
bgh317v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (76)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Palapattu, G. S.
Right arrow Articles by Nelson, W. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Palapattu, G. S.
Right arrow Articles by Nelson, W. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis vol.26 no.7 © Oxford University Press 2004; all rights reserved.

REVIEW

Prostate carcinogenesis and inflammation: emerging insights

Received July 29, 2004; revised and accepted October 12, 2004

Ganesh S. Palapattu 1, Siobhan Sutcliffe 2, Patrick J. Bastian 1, Elizabeth A. Platz 1, 2, Angelo M. De Marzo 1, 3, 4, William B. Isaacs 1, 3 and William G. Nelson 1, 3, 4, *

1 Department of Urology, Johns Hopkins University School of Medicine, 2 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and 3 Department of Oncology and 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

* To whom correspondence should be addressed at: Department of Oncology, Bunting-Blaustein Cancer Research Building, Room 151, 1650 Orleans Street, Baltimore, MD 21231-1000, USA. Tel: +1 410 614 1661; Fax: +1 410 502 9817; Email: bnelson{at}jhmi.edu

Prostate cancer remains a significant health concern for men throughout the world. Recently, there has developed an expanding multidisciplinary body of literature suggesting a link between chronic inflammation and prostate cancer. In support of this hypothesis, population studies have found an increased relative risk of prostate cancer in men with a prior history of certain sexually transmitted infections or prostatitis. Furthermore, genetic epidemiological data have implicated germline variants of several genes associated with the immunological aspects of inflammation in modulating prostate cancer risk. The molecular pathogenesis of prostate cancer has been characterized by somatic alterations of genes involved in defenses against inflammatory damage and in tissue recovery. A novel putative prostate cancer precursor lesion, proliferative inflammatory atrophy, which shares some molecular traits with prostate intraepithelial neoplasia and prostate cancer, has been characterized. Here, we review the evidence associating chronic inflammation and prostate cancer and consider a number of animal models of prostate inflammation that should allow the elucidation of the mechanisms by which prostatic inflammation could lead to the initiation and progression of prostate cancer. These emerging insights into chronic inflammation in the etiology of prostate carcinogenesis hold the promise of spawning new diagnostic and therapeutic modalities for men with prostate cancer.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 In VivoHome page
T. IGUCHI, S. SUGITA, C. Y. WANG, N. B. NEWMAN, T. NAKATANI, and G. P. HAAS
MnSOD Genotype and Prostate Cancer Risk as a Function of NAT Genotype and Smoking Status
In Vivo, January 1, 2009; 23(1): 7 - 12.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. Das, K. Wojno, and M. J. Imperiale
BK Virus as a Cofactor in the Etiology of Prostate Cancer in Its Early Stages
J. Virol., March 15, 2008; 82(6): 2705 - 2714.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
H. Uemura, H. Ishiguro, Y. Ishiguro, K. Hoshino, S. Takahashi, and Y. Kubota
Angiotensin II Induces Oxidative Stress in Prostate Cancer
Mol. Cancer Res., February 1, 2008; 6(2): 250 - 258.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. E. Chavarro, M. J. Stampfer, H. Campos, T. Kurth, W. C. Willett, and J. Ma
A Prospective Study of Trans-Fatty Acid Levels in Blood and Risk of Prostate Cancer
Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 95 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Kiniwa, Y. Miyahara, H. Y. Wang, W. Peng, G. Peng, T. M. Wheeler, T. C. Thompson, L. J. Old, and R.-F. Wang
CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer
Clin. Cancer Res., December 1, 2007; 13(23): 6947 - 6958.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
G. P Risbridger, S. J Ellem, and S. J McPherson
Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling
J. Mol. Endocrinol., September 1, 2007; 39(3): 183 - 188.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. L. Neuhouser, M. J. Barnett, A. R. Kristal, C. B. Ambrosone, I. King, M. Thornquist, and G. Goodman
(n-6) PUFA Increase and Dairy Foods Decrease Prostate Cancer Risk in Heavy Smokers
J. Nutr., July 1, 2007; 137(7): 1821 - 1827.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Chen, F. F. Kadlubar, and J. Z. Chen
DNA supercoiling suppresses real-time PCR: a new approach to the quantification of mitochondrial DNA damage and repair
Nucleic Acids Res., March 13, 2007; (2007) gkm010v2.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. J. Pantuck, J. T. Leppert, N. Zomorodian, W. Aronson, J. Hong, R. J. Barnard, N. Seeram, H. Liker, H. Wang, R. Elashoff, et al.
Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer.
Clin. Cancer Res., July 1, 2006; 12(13): 4018 - 4026.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. J. Kelloff, S. M. Lippman, A. J. Dannenberg, C. C. Sigman, H. L. Pearce, B. J. Reid, E. Szabo, V. C. Jordan, M. R. Spitz, G. B. Mills, et al.
Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer--A Plan to Move Forward
Clin. Cancer Res., June 15, 2006; 12(12): 3661 - 3697.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Nonn, L. Peng, D. Feldman, and D. M. Peehl
Inhibition of p38 by Vitamin D Reduces Interleukin-6 Production in Normal Prostate Cells via Mitogen-Activated Protein Kinase Phosphatase 5: Implications for Prostate Cancer Prevention by Vitamin D.
Cancer Res., April 15, 2006; 66(8): 4516 - 4524.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. E. Garcia, H.-G. Wisniewski, M. S. Lucia, N. Arevalo, T. J. Slaga, S. L. Kraft, R. Strange, and A. P. Kumar
2-Methoxyestradiol Inhibits Prostate Tumor Development in Transgenic Adenocarcinoma of Mouse Prostate: Role of Tumor Necrosis Factor-{alpha}-Stimulated Gene 6
Clin. Cancer Res., February 1, 2006; 12(3): 980 - 988.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Mimeault and S. K. Batra
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
Carcinogenesis, January 1, 2006; 27(1): 1 - 22.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.