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Carcinogenesis Advance Access originally published online on August 10, 2005
Carcinogenesis 2006 27(2):311-318; doi:10.1093/carcin/bgi207
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Carcinogenesis vol.27 no.2 © Oxford University Press 2005; all rights reserved.

Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay

F. Darakhshan 1, C. Badie, J. Moody, M. Coster, R. Finnon, P. Finnon, A.A. Edwards, M. Szluinska, C.J. Skidmore 1, K. Yoshida 2, R. Ullrich 3, R. Cox and S.D. Bouffler *

Radiation Effects Department, Health Protection Agency, Radiation Protection Division, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK, 1 School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading, Berkshire, RG6 6AJ, UK, 2 NIRS, Inage-Ku, Chiba-shi 263, Japan and 3 Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA

* To whom correspondence should be addressed. Tel: +44 1235 822648; Fax: +44 1235 833891; Email: simon.bouffler{at}hpa-rp.org.uk

The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome (chr) 18 with strong association is identified and confirmed by backcross analysis. Additional loci on chrs 8 and 13 show significant association. A key candidate gene Rbbp8 on chr18 is identified. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain. This study demonstrates the strength of utilizing surrogate endpoints of cancer susceptibility in the mapping of mouse loci and identifies additional loci that may affect radiation cancer risk.


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