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Carcinogenesis Advance Access originally published online on December 7, 2005
Carcinogenesis 2006 27(5):982-988; doi:10.1093/carcin/bgi277
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage

Motome Nishikawa-Ogawa, Hideki Wanibuchi, Keiichirou Morimura, Anna Kinoshita, Takayuki Nishikawa, Shuji Hayashi, Yoshihisa Yano 1 and Shoji Fukushima *

Department of Pathology and 1 Department of Biochemistry, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

* To whom correspondence should be addressed. Email: fukuchan{at}med.osaka-cu.ac.jp

N-acetylcysteine (NAC) and S-methylcysteine (SMC), water soluble organosulfur compounds contained in garlic, were evaluated for chemoprevention of hepatocarcinogenesis after 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) initiation in rats. Intergastric treatment with NAC or SMC five times a week resulted in decreased numbers and areas of preneoplastic, glutathione S-transferase placental form (GST-P) positive foci of the liver in a dose-dependent manner. Moreover, cell proliferation was reduced in GST-P positive foci by NAC and SMC. Insulin-like growth factor I (IGF-I) and inducible nitric oxide synthase (iNOS) mRNA expressions were found downregulated in the liver by NAC. The studies indicate that NAC can serve as a chemopreventive agent for rat hepatocarcinogenesis induced by MeIQx by reducing cell proliferation, which may involve IGF-I and iNOS downregulation.


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