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Carcinogenesis Advance Access originally published online on October 4, 2007
Carcinogenesis 2007 28(12):2543-2547; doi:10.1093/carcin/bgm210
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Published by Oxford University Press 2007.

Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

A.V. Brenner*, M.A. Butler1, S.S. Wang, A.M. Ruder2, N. Rothman, P.A. Schulte3, S.J. Chanock4, H.A. Fine5, M.S. Linet and P.D. Inskip

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA
1 Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA
2 Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA
3 Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA
4 Core Genotyping Facility, Advanced Technology Corporation, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, 20892-4605, USA
5 Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892-8200, USA

* To whom correspondence should be addressed. Tel: +301 402-8680; Fax: +301 402 0207; Email: brennera{at}mail.nih.gov

A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, –1098T>G) and IL6 (rs1800795, –174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

Abbreviations: SNP, single-nucleotide polymorphism; NCI, National Cancer Institute; NIOSH, National Institute for Occupational Safety and Health

Received June 14, 2007; revised August 24, 2007; accepted September 12, 2007.


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