Carcinogenesis Advance Access originally published online on August 21, 2006
Carcinogenesis 2007 28(2):350-355; doi:10.1093/carcin/bgl149
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Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center Houston, TX 77030, USA
1 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center Houston, TX 77030, USA
*To whom correspondence should be addressed at: Department of Epidemiology, Unit 1340, The University of Texas M.D. Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA. Tel: +1 713 745 2485; Fax: +1 713 792 4657; Email: xwu{at}mdanderson.org
STK15/Aurora-A is a centrosome-localized serine/threonine kinase that functions primarily in centrosome maturation and mitotic spindle assembly. In a large lung cancer case–control study of 1401 cases and 1397 controls including three ethnic groups, we examined the associations between two non-synonymous SNPs (Phe31Ile and Val57Ile) of the STK15 gene and lung cancer risk. There were statistically significant differences in the distribution of the genotypes (P < 0.0001) and haplotypes (P < 0.0001) by ethnicity for the Phe31Ile, but not the Val57Ile variant. Caucasians with the homozygous variant Phe31Ile genotype (Ile/Ile) were at a significantly reduced risk for lung cancer [odds ratio (OR) = 0.63, 95% confidence interval (CI) = 0.41–0.96]. The variant allele of Val57Ile was not associated with lung cancer risk overall. However, men with the homozygous variant genotype (Ile/Ile) had a reduced lung cancer risk as compared with men with the wild-type genotype (Val/Val) (OR = 0.42, 95% CI = 0.19–0.94). When we performed joint analysis of these two polymorphisms, compared with the reference group (TT + GG, 40.99% of controls), homozygous Ile31 allele/wild-type Val57 allele (AA + GG) carriers (5.45% of controls) exhibited a reduced lung cancer risk (OR = 0.78, 95% CI = 0.63–0.97). This is the first epidemiological study to report significant associations between STK15 polymorphisms and lung cancer risk.
Abbreviations: ESCC, esophageal squamous cell carcinoma; MGB, minor groove binder; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; SNPs, single nucleotide polymorphisms
Received March 20, 2006; revised July 28, 2006; accepted August 4, 2006.
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