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Carcinogenesis Advance Access originally published online on April 13, 2007
Carcinogenesis 2007 28(7):1387-1392; doi:10.1093/carcin/bgm086
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cancer genomics: integrating form and function

So Young Kim1,2 and William C. Hahn1,2,*

1 Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
2 Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA

* To whom correspondence should be addressed. Tel: +1 617 632 2641; Fax: +1 617 632 4005 Email: william_hahn{at}dfci.harvard.edu

The sequencing of the human genome has formed the foundation with which to develop technologies and reagents to perform true genome-scale biological studies. In particular, the development and increasing application of these high-throughput genome-scale technologies have fundamentally altered the way one can approach the analysis of cancer. It is now possible to imagine studies that interrogate the structure, expression and function of every gene in a comprehensive, highly parallel fashion, permitting the development of multidimensional, global views of cancer. In this review, we focus on recent advances in the application of genomic strategies to the study of cancer, with an emphasis on functional genomics and the prospects for integrating the knowledge gained from these approaches to further develop our understanding of cancer and design better therapeutic strategies.

Abbreviations: miRNA, microRNA; siRNA, small interfering RNA

Received February 27, 2007; revised February 27, 2007; accepted April 2, 2007.


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