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Carcinogenesis Advance Access originally published online on September 4, 2008
Carcinogenesis 2008 29(11):2106-2111; doi:10.1093/carcin/bgn206
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis

Seung Bae Rho*, Seung Myung Dong, Sokbom Kang1, Sang-Soo Seo1, Chong Woo Yoo1, Dong Ock Lee1, Jong Soo Woo and Sang-Yoon Park1

Research Institute, National Cancer Center, 809 Madu 1-dong, Ilsan-gu
1 Center for Uterine Cancer, Research Institute, National Cancer Center, dong, Ilsan-gu, Goyang-si, Gyeonggi-do 411-769, Republic of Korea

* To whom correspondence should be addressed. Tel: +82 31 920 2383; Fax: +82 31 920 2337; Email: sbrho{at}ncc.re.kr

Insulin-like growth factor-binding protein-5 (IGFBP-5) is one of the six members of IGFBP family, important for cell growth control, induction of apoptosis and other IGF-stimulated signaling pathways. In this study, we focused on characterizing the specific function of IGFBP-5 as novel antiangiostatic factor. Overexpression of IGFBP-5 suppressed the tube formation as well as the biological functions of angiostatic activity in vivo. This result is due to the reduced expressions of phosphorylated protein kinase B and phosphorylated endothelial NO synthase, which plays important roles in the regulation of angiogenesis when stimulated by vascular endothelial growth factor. Further, IGFBP-5 expression prevented tumor growth and inhibited tumor vascularity in a xenograft model of human ovarian cancer. These results are the first evidence showing that IGFBP-5 plays a role as tumor suppressor by inhibiting angiogenesis.

Abbreviations: Akt, protein kinase B; CAM, chick chorioallantoic membrane; cDNA, complementary DNA; eNOS, endothelial NO synthase; FBS, fetal bovine serum; GFP, green fluorescent protein; HUVEC, human umbilical vein endothelial cell; IGFBP-5, insulin-like growth factor-binding protein; mRNA, messenger RNA; RT–PCR, reverse transcription–polymerase chain reaction; siRNA, small-interfering RNA; VEGF, vascular endothelial growth factor

Received July 2, 2008; revised August 12, 2008; accepted August 23, 2008.


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