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Carcinogenesis Advance Access originally published online on June 9, 2008
Carcinogenesis 2008 29(9):1751-1757; doi:10.1093/carcin/bgm300
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
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CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians

Joke Beuten1, Jonathan A.L. Gelfond2, John J. Byrne1, Ivana Balic3, AnaLisa C. Crandall1, Teresa L. Johnson-Pais4, Ian M. Thompson5, Douglas K. Price6 and Robin J. Leach1,4,5,*

1 Department of Cellular and Structural Biology
2 Department of Epidemiology and Biostatistics
3 Department of Psychiatry
4 Department of Pediatrics, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA
5 Department of Urology, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA
6 Medical Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA

* To whom correspondence should be addressed. Tel: +1 210 567 6947; Fax: +1 210 567 6781; Email: leach{at}uthscsa.edu

Cytochrome P450 1B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones. We compared allele, genotype and haplotype frequencies of six single-nucleotide polymorphisms (SNPs) within CYP1B1 among non-Hispanic Caucasians (496 cases and 498 controls) and Hispanic Caucasians (153 cases and 240 controls). In the Hispanic Caucasians, the GG genotype for rs1056836 decreased the risk for prostate cancer (PCa) when compared with the CC genotype [odds ratio (OR) = 0.31, P = 0.04, 95% confidence interval (CI) = 0.10–0.96]. Among non-Hispanic Caucasian men with more aggressive PCa, the prevalence of several SNPs (rs2567206, rs2551188, rs2617266, rs10012 and rs1056836) was significantly associated with the disease status. A common C-G-C-C-G-A haplotype for rs2567206-rs2551188-rs2617266-rs10012-rs1056836-rs1800440 showed an inverse association with PCa risk in Hispanic Caucasians (OR = 0.19, P = 0.04, 95% CI = 0.04–0.95) and with aggressive disease status (i.e. Gleason score ≥7) in non-Hispanic Caucasian cases (OR = 0.64, P = 0.008, 95% CI = 0.47–0.89). In the non-Hispanic Caucasian cases, a second major haplotype T-A-T-G-C-A was positively associated with the high-grade disease status (OR = 1.77, P = 0.002, 95% CI = 1.24–2.53). Our findings suggest that genetic polymorphisms in CYP1B1 may modify the risk for PCa and support the role of CYP1B1 as a candidate gene for PCa.

Abbreviations: CI, confidence interval; CYP1B1, cytochrome P450 1B1; MAF, minimum allele frequency; OR, odds ratio; PCa, prostate cancer; SNP, single-nucleotide polymorphism

Received August 21, 2007; revised December 20, 2007; accepted December 22, 2007.


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[Abstract] [Full Text] [PDF]


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