Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Moore, M. A.
Right arrow Articles by Bannasch, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moore, M. A.
Right arrow Articles by Bannasch, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1982 Oxford University Press

research-article

The dose dependence and sequential appearance of putative preneoplastic populations induced in the rat liver by stop experiments with N-nitrosomorpholine

Malcolm A. Moore, Doris Mayer and Peter Bannasch 1

Division of Cytopathology, Institute for Experimental Pathology, German Cancer Research Center D-6900 Heidelberg, FRG

1To whom reprint requests should be addressed.

Different doses of N-nitrosomorpholine (NNM) (80, 120, 160, 200 mg/l drinking water) were administered for various periods of time (1, 4, 7, 14, 20 weeks) to male Sprague-Daw-ley rats in order to investigate the dose dependence and sequential appearance of preneoplastic and neoplastic lesions in the liver. With all dose levels studied a sequence was established leading from dear cell and acidophilic cell glycogen storage foci through mixed cell foci and neoplastic nodules to hepatocellular carcinomas. The first appearance and frequency of the different lesions investigated proved dependent on dose of carcinogen administered. Morphometric analysis demonstrated that the rare small clear cell foci apparent after 7 weeks treatment with NNM increase in number and size with progression through the sequence to carcinomas without further administration of carcinogen. No evidence was found to suggest that pronounced focal populations were reversible upon cessation of NNM-treatment under the present experimental conditions.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
F. Dombrowski, C. M. Jost, S. Manekeller, and M. Evert
Cocarcinogenic Effects of Islet Hormones and N-Nitrosomorpholine in Hepatocarcinogenesis after Intrahepatic Transplantation of Pancreatic Islets in Streptozotocin-Diabetic Rats
Cancer Res., August 1, 2005; 65(15): 7013 - 7022.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Sukata, S. Uwagawa, K. Ozaki, K. Sumida, K. Kikuchi, M. Kushida, K. Saito, K. Morimura, K. Oeda, Y. Okuno, et al.
{alpha}2-Macroglobulin: A Novel Cytochemical Marker Characterizing Preneoplastic and Neoplastic Rat Liver Lesions Negative for Hitherto Established Cytochemical Markers
Am. J. Pathol., November 1, 2004; 165(5): 1479 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
C. Ittrich, E. Deml, D. Oesterle, K. Kuttler, W. Mellert, S. Brendler-Schwaab, H. Enzmann, L. Schladt, P. Bannasch, T. Haertel, et al.
Prevalidation of a Rat Liver Foci Bioassay (RLFB) Based on Results from 1600 Rats: A Study Report
Toxicol Pathol, January 1, 2003; 31(1): 60 - 79.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
H. Enzmann, C. Kuhlem, G. Kaliner, E. Loser, and P. Bannasch
Rapid Induction of Preneoplastic Liver Foci in Embryonal Turkey Liver by Diethylnitrosamine
Toxicol Pathol, September 1, 1995; 23(5): 560 - 569.
[Abstract] [PDF]

Home page
 Toxicol Ind HealthHome page
E. Rinde, R. Hill, A. Chiu, and B. Haberman
Proliferative Hepatocellular Lesions of the Rat: Review and Future Use in Risk Assessment
Toxicology and Industrial Health, January 1, 1987; 3(1): 145 - 166.
[PDF]

Home page
 Toxicol PatholHome page
A. Columbano, S. Dessi, G. M. Ledda-Columbano, C. Chiodino, P. Coni, P. Pani, and K. N. Rao
HMP-Shunt and Cholesterol Metabolism in Experimental Models Involving Normal and Preneoplastic Liver Growth
Toxicol Pathol, January 1, 1987; 15(1): 43 - 50.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
P. Bannasch, M. A. Moore, F. Klimek, and H. Zerban
Biological markers of preneoplastic foci and neoplastic nodules in rodent liver
Toxicol Pathol, February 1, 1982; 10(2): 19 - 34.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.