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© 1982 Oxford University Press

research-article

The influence of mineral dusts on metabolic co-operation between mammalian cells in tissue culture

M. Chamberlain 1

Medical Research Council Pneumoconiosis Unit, Llandough Hospital, Penarth, South Glamorgan CF6 1XW, UK

1Present address: Environmental Safety Division, Unilever Research, Colworth House, Shambrook, Bedford, UK.

Carcinogenic UICC amosite asbestos has been tested in V79–4 cultures to determine whether it acts like a tumour promoter, such as TPA, by inhibiting metabolic co-operation. TPA inhibited metabolic co-operation at the non-toxic dose of 0.01 µg/ml but UICC amosite did not inhibit the cell to cell communication even at a toxic dose. Min-U-Sil silica and ballmilled amosite which were included as non-carcinogenic control dusts similarly did not inhibit metabolic co-operation.


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