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© 1982 Oxford University Press

other

Induction of colorectal squamous cell carcinomas in rats by dextran sulfate sodium

Iwao Hirono 1, Kazunori Kuhara 1, Taketo Yamaji 1, Shigetoshi Hosaka 1 and Leon Golberg 2

1Department of Carcinogenesis and Cancer Susceptibility, Institute of Medical Science, University of Tokyo Shirokanedai 4-6-1, Minatoku, Tokyo 108, Japan
2Division of Community/Occupational Medicine Box 2914, Duke University Medical Center, Durham, NC 27710, USA

ACI rats, 15 males and 15 females, were fed a diet containing 1% dextran sulfate sodium for 660 days. Twenty two of 29 surviving rats developed intestinal tumors between 288 and 660 days. Most tumors consisted of papillomas, and 4 squamous cell carcinomas were also induced, in addition to adenomas and adenocarcinomas. No intestinal tumors were observed in rats of the control group.


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