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© 1982 Oxford University Press

other

Decreased levels of S-adenosylmethionine in the livers of rats fed phenobarbital and DDT

Narayan Shivapurkar and Lionel A. Poirier

Nutrition and Metabolism Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute FCRF, Frederick, MD 21701, USA.

Chronic feeding of the liver tumour promoters phenobarbital (PB) and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT) to male weanling rats at levels of 0.05% in the diet for 1,3 and 5 weeks reduced the hepatic S-adenosylmethionine (AdoMet) contents by ~50%. Such reductions were inhibited by the simultaneous feeding of choline chloride and were completely prevented by the dietary administration of methionine. AdoMet levels >100 µg/g liver were noted in rats receiving PB + methionine for 1 week, DDT + methionine for 1 week or methionine alone for 5 weeks. These results are consistent with the hypothesis that the liver tumour promoting activities of PB and DDT may occur in part through a hepatic methyl insufficiency.


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