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© 1982 Oxford University Press

other

Induction of pancreatic DNA damage and nodules in rats treated with N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine

Daniel S. Longnecker, Joanne Zurlo 1, Thomas J. Curphey and William E. Adams

Department of Pathology, Dartmouth Medical School Hanover, NH 03755, USA

DNA damage was demonstrated by alkaline elution analysis in pancreas of rats treated with 100 mg/kg N-nitrosobis(2-oxopropyl)amine (BOP) and 20 mg/kg N-nitroso(2-hydroxy-propyl)2-oxopropyl)amine (HPOP). Young rats were treated with a single dose of BOP or HPOP and autopsied 4 months later. Histologically the pancreases contained multiple foci and nodules of atypical acinar cells which were not seen in controls.


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