Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Flaks, B.
Right arrow Articles by Milsom, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flaks, B.
Right arrow Articles by Milsom, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1982 Oxford University Press

research-article

A comparative study of ultrastructural changes induced by chronic treatment with 3'-methyl-4-dimethylaminoazobenzene and the non-carcinogen 3'-methyl-4-diethylaminoazobenzene in the rat hepatocyte

Bojan Flaks 1, Antonia Flaks 2 and Ann Milsom 1

1Department of Pathology, University of Bristol Medical School Bristol BS8 1TD
2Cancer Research Unit, University of York Heslington, York YO1 5DD, UK

Male Leeds strain rats were fed a diet containing either 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) or an equimolar level of the non-carcinogenic azo dye, 3'-methyl-4-diethylaminoazobenzene (3'-MeDEAB), for up to 26 weeks. The hepatic tissues were studied by electron microscopy. In contrast to 3'-MeDAB, which induced an early dispersal and reduction of the rough endoplasmic reticulum (ER) in hepatocytes together with nucleolar segregation, proliferation of the smooth ER, mitochondrial abnormalities, bile canalicular dilatation, Golgi atrophy and increased numbers of lysosomes, the effects of 3'-MeDEAB were largely confined to a proliferation of smooth ER. In the light of earlier studies on carcinogen/non-carcinogen pairs of chemicals, the present results appear to support the view that the rough ER lesion may be specific to the action of hepatocarcinogens.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.