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© 1982 Oxford University Press

research-article

Ultrastructural analysis of pancreatic carcinogenesis. VI. Early changes in hamster acinar cells induced by N-nitroso-bis(2-hydroxy-propyl)amine

Bojan Flaks 1, Malcolm A. Moore 1 2 and Antonia Flaks 3

1Department of Pathology, University of Bristol Medical School, University Walk Bristol BS8 1TD
3Cancer Research Unit, University of York Heslington, York YO1 5DD, UK.

2Present address: Deutsches Krebsforschungszentrum, Institut fur Experimentelle Pathologie, Heidelberg, FRG.

Male Syrian golden hamsters were given weekly s.c. injections of 250 mg/kg body weight of N-nitroso-bis(2-hydroxypropyl)amine (BHP) for up to 15 weeks. Electron microscope studies were carried out on early changes in the exocrine pancreas of these hamsters from 2 weeks to 15 weeks. The majority of observed alterations occurred in the acinar cells and included the appearance of "dark" and "light" cells, the former showing nuclear shrinkage and irregularity but maintaining a normal rough endoplasmic reticulum (ER) and zymogen content. The "light" cells exhibited a variety of early fine structural alterations including conformational changes in their rough ER, together with a reduction in zymogen granules, increased autophagic vacuoles and Golgi hypertrophy. Ducts and ductules were relatively unaffected. The observations indicate that the acinar cells are most affected, morphologically, by BHP and are consistent with the view that these cells are the primary target for BHP.


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