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© 1983 Oxford University Press

other

Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model

Miriam B. Ahluwalia, Joel Rotstein, Masae Tatematsu, M.W. Roomi and Emmanuel Farber

Department of Pathology, University of Toronto Toronto, Ont. M5S 1A8, Canada

This study was undertaken to observe whether the administration of reduced glutathione intragastrically to male Fischer 344 rats during the precancerous steps of liver carcinogenesis has any protective effect on the development of hepatocellular carcinoma. Hepatocyte nodules were induced in the liver with a single initiating dose of diethylnitrosamine followed by selection of resistant hepatocytes to generate nodules by a two week exposure to dietary 2-acetylamino-fluorene coupled with partial hepatectomy. Animals had hepatocyte (‘hyperplastic’) nodules when examined by iaparotomy at three months. At that time, the animals were divided into two groups. One received daily intragastric giuta-thione for 8 months while the other received no further treatment. An additional control group received only the selecting (promoting) regimen with no initiator or glutathione. At 12 months, the animals receiving the initiator and promoter regimen had a 65% incidence of hepatocellular carcinoma and those receiving glutathione in addition bad a 71% incidence. Under these experimental conditions, the long term administration of glutathione appears to have no observable influence on liver cancer development in this model.


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Home page
 Toxicol PatholHome page
C. F. Cesarone, L. Scarabelli, and M. Orunesu
Effect of Glutathione and N-Acetylcysteine on Hepatocellular Modifications Induced by 2-Acetylaminofluorene
Toxicol Pathol, April 1, 1986; 14(4): 445 - 450.
[Abstract] [PDF]


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