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© 1983 Oxford University Press

research-article

Synthesis of putative oxidized metabolites of 8-methylbenzo[a]pyrene

Hongmee Lee, Jagdish Sheth and Ronald G. Harvey 1

Ben May Laboratory for Cancer Research, The University of Chicago Chicago, IL 60637, USA

1Address correspondence to Ronald G. Harvey, Ben May Laboratory for Cancer Research, Box 424, The University of Chicago, 950 E. 59th Street, Chicago, IL 60637, USA.

Synthesis is described of trans-7,8-dihydroxy-7,8-dihydro-8-methylbenzo[a]pyrene and trans-7,8-dihydroxy-anti-9,10-epoxy-8-methyl-7,8,9,10-tetrahydrobenzo[a]pyrene, potential proximate and ultimate carcinogenic metabolites, respecively, of 8-methylbenzo[a]pyrene.


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