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© 1983 Oxford University Press

research-article

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition

Ryuichi Kato 1, Teruo Nakadate 1, Satoshi Yamamoto 1 and Takashi Sugimura 2

1Department of Pharmacology, School of Medicine, Keio University 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
2National Cancer Center Research Institute 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan

Quercetin (30 µmol/mouse) markedly suppressed the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA, 20 nmol/mouse) on skin tumor formation in the CD-1 mice initiated by 7,12-dimethylbenz[a]anthracene (200 nmol/mouse). TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10–30 µmol/mouse), but it failed to inhibit the stimulation, of epidermal DNA synthesis by TPA. In addition, quercetin potently inhibited lipoxygenase from 105 000 g supernatant of epidermal homogenate of mice. The 50% inhibition of lipoxygenase was observed by quercetin at 1.3 µM. These results suggest that the inhibition of lipoxygenase by quercetin is one of the major actions of the above agent to inhibit tumor promotion and TPA-induced ODC activity.


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