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© 1983 Oxford University Press

research-article

Binding of 5,9-dimethyl dibenzo[c,g]carbazol, a potent hepatocarcinogen, to mouse hepatic cytosolic proteins

Danièle Valéro, François Périn and François Zajdela

Unité de Physiologie Cellulaire, INSERM (U 22), Institut Curie Bâtiment 110, Centre Universitaire, F-91405 Orsay, France

5,9-Dimethyl dibenzo[c,g]carbazole (5,9-diMe DBC) is a powerful organ-specific liver carcinogen in mice. Its binding to liver cytosolic proteins has been studied in vivo and in vitro with the aid of a tritium-labelled sample. Only two classes of proteins fractionated on Sephadex G100 appear to be involved in this binding: one class of high mol. wt. proteins (>100 000) and another of around 45 000. The latter class contains all the glutathione-S-transferase activity (GST). The bound radioactivity has been determined after incubation in the presence or absence of microsomes. The in vivo binding has been investigated as a function of time. A highly significant covalent and noncovalent binding of 5,9-diMe DBC mostly to GST has been observed after metabolic activation.


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