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© 1983 Oxford University Press

other

Squamous metaplasia of tracheal submucosal glands induced by benzo[a]pyrene and vitamin A deficiency

Dharam P. Chopra and Rodger A. Cooney

Southern Research Institute P.O. Box 55305, Birmingham, AL 35255, USA

The effects on tracheal glands of benzo[a]pyrene and of vitamin A deficiency were examined in explants derived from normal and vitamin A deficient hamsters, respectively. Both treatments caused hyperplasia and squamous metaplasia of the tracheal glands. It is suggested that a proportion of respiratory tract lesions may originate in tracheal glands.


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