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© 1983 Oxford University Press

other

Effect of 12-O-tetradecanoylphorbol-13-acetate on polyamine metabolism in mice sensitive and resistant to lung-adenoma

Susan Bardócz, P. Rády 1, I. Ember 1, T. Karsai and P. Kertai 1

Department of Biochemistry, University Medical School of Debrecen H-4012 Debrecen, POB 6, Hungary
1Department of Hygiene and Epidemiology, University Medical School of Debrecen H-4012 Debrecen, POB 6, Hungary

Ornithine decarboxylase activity and polyamine concentrations were determined in the lungs of mice from 0 to 20 h after treatment with 12-O-tetradecanoylphorbol-13-acetate (17.7 nmol in 0.2 ml acetone/mouse). In CFLP mice, which responded to carcinogen with development of lung-adenomas, a single topical application of TPA to hairless mouse skin increased ornithine decarboxylase activity in the lung. In contrast, in C3H/He-mg mouse strain, which were resistant to lung-adenoma production, TPA application did not increase ODC activity of the lungs.


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