Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hiasa, Y.
Right arrow Articles by Fujita, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hiasa, Y.
Right arrow Articles by Fujita, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983 Oxford University Press

research-article

Effect of varying the duration of exposure to phenobarbital on its enhancement of N-bis(2-hydroxypropyl)nitrosamine-induced thyroid tumorigenesis in male Wistar rats

Yoshio Hiasa, Yoshiteru Kitahori, Noboru Konishi, Noboru Enoki and Toyahisa Fujita

1st Department of Pathology, Nara Medical University Kashihara, Nara 634, Japan

Male Wistar rats were injected s.c. with a single dose of 280 mg N-bis(2-hydroxypropyl)nitrosamine (DHPN) per 100 g body weight and the effect of subsequent exposure to 500 p.p.m. phenobarbitone (PB) for 6, 12 and 19 weeks on development of thyroid tumors was studied. Exposure to PB for 12 or 19 weeks enhanced the development of thyroid tumors in the rats. The incidences of thyroid tumors in DHPN-treated rats at the end of the experiment for 20 weeks were 87%, 83%, 42% and 37%, respectively, in rats given PB for 19 weeks, 12 weeks, and 6 weeks, and in those given no PB. The incidence of thyroid cancers was 12% in rats given DHPN and then PB for 19 weeks. The total numbers of thyroid tumors were 241, 125, 65 and 23, respectively, in DHPN-treated rats given PB for 19 weeks, 12 weeks, and 6 weeks, and in those given no PB. Thus, the total numbers of thyroid tumors were correlated with the period of PB treatment.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
C. D. Klaassen and A. M. Hood
Effects of Microsomal Enzyme Inducers on Thyroid Follicular Cell Proliferation and Thyroid Hormone Metabolism
Toxicol Pathol, January 1, 2001; 29(1): 34 - 40.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
J. Kanno, H. Onodera, K. Furuta, A. Maekawa, T. Kasuga, and Y. Hayashi
Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid
Toxicol Pathol, February 1, 1992; 20(2): 226 - 235.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.