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© 1984 Oxford University Press

other

The influence of 18 environmentally relevant polycyclic aromatic hydrocarbons and Clophen A50, as liver monooxygenase inducers, on the mutagenic activity of benz[a]anthracene in the Ames test

K. Norpoth , A. Kemena , J. Jacob 1 and C. Schümann 

Institut für Hygiene und Arbeitsmedizin des Universitãtsklinikum Hufe-landstr. 55, 4300 Essen
1Biochemisches Institut für Umweltcarcinogene Sieker Landstr. 19, 2070 Ahrensburg, FRG

In the presence of various liver S9 preparations induced by different polycyclic aromatic hydrocarbons, the weak carcinogen, benz[a]anthracene, exhibited mutagenic activities comparable to those of benzo[a]pyrene in the Ames test. A series of positive correlations were found between mutagenic activity and the hydroxylation products of benz(a)anthracene at the 3, 4-, 5, 6- and 8, 9-positions, of which 5, 6-position was the most pronounced one (p < 0.01). Our results suggest that the observed mutagenic activity is due mainly to the generation of K-region epoxides.


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