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© 1984 Oxford University Press

other

Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates

Hiroko Ohgaki , Norio Matsukura , Kazuhide Morino , Takashi Kawachi , Takashi Sugimura  and Shozo Takayama 1

Biochemistry Division, National Cancer Center Research Institute 1-1, Tsukiji 5 chome, Chuo-ku, Tokyo 104
1Department of Experimental Pathology, Cancer Institute 1-37, Kami-Ikebukuro 1 chome, Toshima-ku, Tokyo 170, Japan

2-Amino-6-methyldipyrido[1,2-a:3',2' -d]imidazole and 2-aminodipyrido[1,2-a:3',2'-d]imidazole, potent mutagens from glutamic acid pyrolysate, were given orally to CDF1 mice of both sexes at concentrations of 0.05% in pellet diet. 2-Amino-3-methyl-9H-pyrido[2,3-b]indole and 2-amino-9H-pyrido[2,3-b]indole, potent mutagens from soybean globulin pyrolysate, were given to CDF1 mice of both sexes at concentrations of 0.08%. Hepatocellular carcinomas and hemangio-endothelial sarcomas in the brown adipose tissue were induced in high incidence by all these compounds.


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