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© 1984 Oxford University Press

other

Xeroderma pigmentosum: in vitro complementation of DNA repair endonuclease

Dag Helland, Ruth Kleppe, Johan R. Lillehaug and Kjell Kleppe 1

Department of Biochemistry, University of Bergen Årstadveien 19, 5000 Bergen, Norway

1To whom reprint requests should be sent

The DNA repair endonuclease activity has been studied in several xeroderma pigmentosum (XP) cell lines of complementation groups A and C. øX174 RFI DNA treated with u.v.-light or OsO4 was used as a substrate. All XP cells tested appeared to lack this enzyme compared to control cells. However, when extracts from complementation groups A and C were mixed, activity levels dose to that of the control cells were found, clearly indicating that the two cell lines can complement each other with regard to the DNA repair endonuclease activity. The XP cells were found to contain normal levels of AP-endonuclease.


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