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© 1984 Oxford University Press

other

Determination of carcinogenic synergism from the latent period

Arnold E. Reif  and Theodore Colton 

Mallory Institute of Pathology, Boston City Hospital 80 East Concord Street, Boston, MA 02118, USA
Department of Epidemiology and Biostatistics, Boston University School of Medicine 80 East Concord Street, Boston, MA 02118, USA

We present a method for determining the presence or absence of synergism between two carcinogens A and B from the latent period of tumors. The method is applied to data consisting of the means and standard deviations of the times at which tumors become palpable and at which death from tumor occurs in animals of three groups: those given carcinogen A alone, those given B alone, and those given both A and B. Synergism was absent in the data examined.


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