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© 1985 Oxford University Press

other

Influence on cell-cell communication (dye-transfer) of the oncogenic ß-blocker DL-ZAMI 1305: possible relation to tumor promotion

Giovanna Mazzoleni, Giovanni Ragnotti, Taira Enomoto 1 2 and Hiroshi Yamasaki 1

Chair of General Pathology, Department of Biomedical Sciences, Faculty of Medicine, University of Brescia via Valsabbina 19, 25124 Brescia Italy
1Division of Environmental Carcinogenesis, International Agency for Research on Cancer 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France

The effect of the oncogenic ß-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butyl-amino-propan-2-ol (DL-ZAMI 1305) on intercellular communication between cultured cells was studied. Intercellular communication of Chinese hamster V79 cells was measured by the dye-transfer method in which the spread of intracellularly microinjected fluorescent probe, Lucifer Yellow CH, through gap-junctions was used as an index of intercellular communication. When V79 cells are cultured with non-toxic doses (1–60 µg/ml) of DL-ZAMI 1305, a significant inhibition of dye-transfer is observed after 4 h. The inhibition is dose-related and >90% inhibition is seen at the dose of 50 µg/ml. When DL-ZAMI 1305 is added at 0 and 24 h of experiment, its inhibitory effect is maintained for at least 48 h at high doses (50–60 µg/ml), whereas for lower doses of DL-ZAMI 1305, some recovery is seen after 24 h incubation. These results are suggestive of a possible tumor-promoting activity of DL-ZAMI 1305; in vivo studies on this carcinogen are in progress.


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Home page
 Toxicol PatholHome page
N. Pacces, M. Braga, T. Zavanella, M. Presta, and G. Ragnotti
Further Studies on the Tumor-Initiating Activity of the Beta-Blocker DL-ZAMI 1305
Toxicol Pathol, April 1, 1986; 14(4): 470 - 476.
[Abstract] [PDF]


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