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© 1985 Oxford University Press

other

Syncarcinogenic effects of methyl methanesulfonate with methylazoxymethanol acetate in rat small intestine and liver

Hideki Mori 1, Tokuro Kuniyasu, Shigeyuki Sugie, Hiroto Shima and Masayoshi Takahashi

Department of Pathology, Gifu University School of Medicine 40 Tsukasa-machi, Gifu 500, Japan

1To whom reprint requests should be sent

The carcinogenic potency of methyl methanesulfonate (MMS) and its combination effect with methylazoxymethanol (MAM) acetate were evaluated in rats. MMS was suggested to be weakly carcinogenic for the small intestine. Syncarcinogenic effects of MMS and MAM acetate which could be due to summation of their genotoxic influences were obtained in the small intestine and liver.


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