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© 1985 Oxford University Press

other

Identification and quantification of 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline (4,8-DiMeIQx) in beef extract

Makoto Takahashi 1, Keiji Wakabayashi 1 3, Minako Nagao 1, Ziro Yamaizumi 1, Shigeaki Sato 1, Naohide Kinae 2, Isao Tomita 2 and Takashi Sugimura 1

1National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104
2Shizuoka College of Pharmacy 2-1, Oshika 2-chome, Shizuoka 422, Japan

3To whom reprint requests should be sent

2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-Di-MeIQx) was found in bacteriological-grade beef extract by liquid chromatographies with electrochemical detection and a photodiode array detector. 4,8-DiMeIQx was estimated to be present at a level of 10.0 ng per g of beef extract, and to account for 9% of the total mutagenicity of the extract.


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