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© 1985 Oxford University Press

research-article

Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil

B.R. Reeves , G. Casey , H. Harris  and W.J. Dinning 1

Section of Human Genetics, Institute of Cancer Research, Royal Marsden Hospital Fulham Road, London SW3 6JJ
1Moorfields Eye Hospital City Road, London, UK

We have studied the long-term effects of chlorambucil treatment on the chromosomes of peripheal blood lymphocytes from patients with uveitis. Amounts of chromosome damage (breaks and rearrangements) were found to vary between individuals, but tended to increase with the cumulative dose. Some patients were found to have persistently high levels of chromosome damage many years after treatment had been completed.


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