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© 1985 Oxford University Press

other

Effect of increased intake of vitamin C on the mutagenic activity of gastric juice and intragastric concentrations of ascorbic acid

H.J. O'Connor 1 5, N. Habibzedah 2, C.J. Schorah 2, A.T.R. Axon 1, S.E. Riley 3 and R.C. Garner 4

1Gastroenterology Unit, General Infirmary Leeds
2Department of Chemical Pathology, General Infirmary Leeds
3Microtest Research Limited York UK
4Cancer Research Unit, University of York UK

5To whom reprint requests should be sent: Senior Registrar in Medicine, Selly Oak Hospital, Birmingham, B29 6JD, UK

Mutagenic activity, ascorbic acid levels and pH were measured in fasting gastric juice from eight patients given oral supplements of vitamin C (1 g qid x 7 days). Supplementation significantly reduced mutagenic activity and increased intragastric ascorbate levels without altering gastric pH. These results demonstrate for the first time the relation between intragastric ascorbate levels, mutagenic activity and oral supplements of vitamin C. The findings are discussed in relation to the possible chemoprevention of gastric cancer.


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