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© 1987 Oxford University Press

other

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA

Hiroshi Kasai, Susumu Nishimura, Yuji Kurokawa 1 and Yuzo Hayashi 2

Biology Division, National Cancer Center Research Institute 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan
1Division of Toxicology 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan
2Division of Pathology, National Institute of Hygienic Sciences 1-18-1 Kamiyoga, Setagaya-ku,Tokyo 158, Japan

Following oral administration of a renal carcinogen, potassium bromate (KBrO3), to the rat, a significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) in kidney DNA was observed. In the liver, a non-target tissue, the increase in 8-OH-dG was not significant. The non carcinogenic oxidants, NaCIO and NaCIO2, had no effect on 8-OH-dG formation in kidney DNA. These results suggest that formation of 8-OH-dG in tissue DNA is closely related to KBrO3 carcinogenesis.


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