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© 1987 Oxford University Press

research-article

Promotion of skin tumours by TPA in the progeny of mice exposed pre-natally to DMBA

N. Napalkov, A. Likhachev, V. Anisimov, A. Lokitonov 1, M. Zabezhinski, A. Ovsyannikov, J. Wahrendorf 1 3, H. Becher 2 and L. Tomatis 1

N.N.Petrov Research Institute of Oncology 68 Leningradskaya St, Pesochny-2, 188646 Leningrad, USSR
1International Agency for Research on Cancer 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France
3Present address:Department of Epidemiology, Institute of Documentation, Information and Statistics German Cancer Research Center, Im Neuenheimer Feld 280, 6900 Heidelberg, FRG
2Institut für Präventionsforschung und Sozialmedizin Präsident Kennedy-Platz 1, 2800 Bremen, FRG

Pregnant SHR mice were treated once with 7,12-dimethyl-benz[a]anthracene (DMBA) on day 17–19 of gestation, and F1 and F2 descendants received multiple skin applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice a week for 24 weeks beginning at 12 weeks of age. Post-natal promoter treatment resulted in a high incidence of skin twmours in F1 and F2 mice (37.3 and 19.7%, respectively), whereas only 6.6% of control animals treated with TPA only developed skin tumours. DMBA was shown previously to be capable of in itiating skin carcinogenesis transplacentally; however, our results on the second generation provide suggestive evidence of hereditary transmission of at least part of the initiating action of this carcinogen.


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