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© 1987 Oxford University Press
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Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethyihydrazine-induced colon cancer
Section of Gastrointestinal Oncology, Department of Medical Oncology Box 68, M.D.Anderson Hospital and Tumor Institute, 6723 Bertner Ave., Houston, TX 77030, USA
Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.
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