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© 1988 Oxford University Press

research-article

Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell

John A. McBain, George R. Pettit 1 and Gerald C. Mueller 2

McArdle Laboratory for Cancer Research, The University of Wisconsin Madison, WI 53706
1Cancer Research Institute and Department of Chemistry, Arizona State University Tempe, AZ 85287, USA

2To whom reprint requests should be sent

12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatln 1, a macrocyclic lactone, completely counter-acts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.


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