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© 1988 Oxford University Press

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Suppression of EGF binding in rat liver by the hypolipidemic peroxisome proliferators, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-ß-hydroxyethyl)acetamide and di(2-ethylhexyl)phthalate

Chhanda Gupta 1, Atsuo Hattori and Hisashi Shinozuka

Department of Pathology, University of Pittsburgh, School of Medicine Pittsburgh, PA 15261, USA

1To whom reprint requests should be sent

Dietary administration of 4-chloro-6-(2,3-xylidino)-2- pyrimidinylthio(N-ß-hydroxyethyl)acetamlde (BR931) and di(2-ethylhexyl)phthalate (DEHP), hypolipidemic agents, to rats for 3–35 days induced a marked reduction in the hepatocyte surface and intracellular binding of [125I]EGF without affecting its binding affinity. The reduction was apparent after 3 days' feeding of BR931 and the magnitude of the reduction was consistently higher in hepatocytes of BR931-treated rats than those of DEHP-treated rats. The liver extracts and the sera from rats fed BR931 or DEHP for 4 weeks showed no inhibitory effects on the EGF binding of hepatocytes from rats fed a basal diet. Possible significance of the changes in relation to their hepatocarcinogenic action was discussed.


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