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© 1988 Oxford University Press

other

Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro

Molly F. Kulesz-Martin, Remedios Penetrante 1 and Christopher J. East

Grace Cancer Drug Center 666 Elm Street, Buffalo, NY 14263, USA
1Department of Pathology, Roswell Park Memorial Institute 666 Elm Street, Buffalo, NY 14263, USA

Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.


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