Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (184)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pence, B. C.
Right arrow Articles by Buddingh, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pence, B. C.
Right arrow Articles by Buddingh, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 Oxford University Press

other

Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3

Barbara C. Pence and Fred Buddingh

Department of Pathology, Texas Tech University Health Sciences Center Lubbock, TX 79430, USA

A 2 x 2 x 2 factorial experimental design was used to investigate the effects of supplemental calcium (Ca) (0.5% versus 1.0% of diet as Ca gluconate) and vitamin D3 (D) (1000 IU/kg diet versus 2000 IU/kg diet) on 1,2-dimethylhydrazine-induced colon carcinogenesis in male F344 rats promoted with a 20% corn oil diet. Animals on the high-fat (HF) diet had an increased tumor incidence compared to the low-fat (LF) control diet (86% versus 53%, P < 0.05) and supplemental Ca or D reduced this to or below the LF incidence (HF + Ca: 53%, HF + D: 47%). However, supplemental Ca or D had no inhibitory effect with LF diets (LF + Ca: 67%, LF + D: 60%). The results of this study indicate a possible role for supplemental Ca or D in the prevention of colon cancer, effective only in HF diets.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. M. Dong, C. M. Ulrich, L. Hsu, D. J. Duggan, D. S. Benitez, E. White, M. L. Slattery, B. J. Caan, J. D. Potter, and U. Peters
Genetic Variation in Calcium-Sensing Receptor and Risk for Colon Cancer
Cancer Epidemiol. Biomarkers Prev., October 1, 2008; 17(10): 2755 - 2765.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Zhou, M. Liu, Y. Zhai, and W. Xie
The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells
Mol. Endocrinol., April 1, 2008; 22(4): 868 - 880.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. V. Grau, J. A. Baron, R. S. Sandler, K. Wallace, R. W. Haile, T. R. Church, G. J. Beck, R. W. Summers, E. L. Barry, B. F. Cole, et al.
Prolonged Effect of Calcium Supplementation on Risk of Colorectal Adenomas in a Randomized Trial
J Natl Cancer Inst, January 17, 2007; 99(2): 129 - 136.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. Lin, S. M. Zhang, N. R. Cook, J. E. Manson, I-M. Lee, and J. E. Buring
Intakes of Calcium and Vitamin D and Risk of Colorectal Cancer in Women
Am. J. Epidemiol., April 15, 2005; 161(8): 755 - 764.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. M. Harris and V. L. W. Go
Vitamin D and Colon Carcinogenesis
J. Nutr., December 1, 2004; 134(12): 3463S - 3471S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
H. L Newmark, R. P Heaney, and P. A Lachance
Should calcium and vitamin D be added to the current enrichment program for cereal-grain products?
Am. J. Clinical Nutrition, August 1, 2004; 80(2): 264 - 270.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
K. Wallace, J. A. Baron, B. F. Cole, R. S. Sandler, M. R. Karagas, M. A. Beach, R. W. Haile, C. A. Burke, L. H. Pearson, J. S. Mandel, et al.
Effect of Calcium Supplementation on the Risk of Large Bowel Polyps
J Natl Cancer Inst, June 16, 2004; 96(12): 921 - 925.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. V. Grau, J. A. Baron, R. S. Sandler, R. W. Haile, M. L. Beach, T. R. Church, and D. Heber
Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial
J Natl Cancer Inst, December 3, 2003; 95(23): 1765 - 1771.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. M. Boyapati, R. M. Bostick, K. A. McGlynn, M. F. Fina, W. M. Roufail, K. R. Geisinger, M. Wargovich, A. Coker, and J. R. Hebert
Calcium, Vitamin D, and Risk for Colorectal Adenoma: Dependency on Vitamin D Receptor BsmI Polymorphism and Nonsteroidal Anti-Inflammatory Drug Use?
Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 631 - 637.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Makishima, T. T. Lu, W. Xie, G. K. Whitfield, H. Domoto, R. M. Evans, M. R. Haussler, and D. J. Mangelsdorf
Vitamin D Receptor As an Intestinal Bile Acid Sensor
Science, May 17, 2002; 296(5571): 1313 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
K. Wu, W. C. Willett, C. S. Fuchs, G. A. Colditz, and E. L. Giovannucci
Calcium Intake and Risk of Colon Cancer in Women and Men
J Natl Cancer Inst, March 20, 2002; 94(6): 437 - 446.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
J. Ma, E. Giovannucci, M. Pollak, J. M. Chan, J. M. Gaziano, W. Willett, and M. J. Stampfer
Milk Intake, Circulating Levels of Insulin-Like Growth Factor-I, and Risk of Colorectal Cancer in Men
J Natl Cancer Inst, September 5, 2001; 93(17): 1330 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
E. A. Platz, S. E. Hankinson, B. W. Hollis, G. A. Colditz, D. J. Hunter, F. E. Speizer, and E. Giovannucci
Plasma 1,25-Dihydroxy- and 25-Hydroxyvitamin D and Adenomatous Polyps of the Distal Colorectum
Cancer Epidemiol. Biomarkers Prev., October 1, 2000; 9(10): 1059 - 1065.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
G. D. Díaz, C. Paraskeva, M. G. Thomas, L. Binderup, and A. Hague
Apoptosis Is Induced by the Active Metabolite of Vitamin D3 and Its Analogue EB1089 in Colorectal Adenoma and Carcinoma Cells: Possible Implications for Prevention and Therapy
Cancer Res., April 1, 2000; 60(8): 2304 - 2312.
[Abstract] [Full Text]

Home page
 J. Am. Coll. Nutr.Home page
P. R. Holt
Dairy Foods and Prevention of Colon Cancer: Human Studies
J. Am. Coll. Nutr., October 1, 1999; 18(90005): 379S - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
M. Lipkin and H. L. Newmark
Vitamin D, Calcium and Prevention of Breast Cancer: A Review
J. Am. Coll. Nutr., October 1, 1999; 18(90005): 392S - 397.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Khare, M. Bissonnette, B. Scaglione-Sewell, R. K. Wali, M. D. Sitrin, and T. A. Brasitus
1,25-Dihydroxyvitamin D3 and TPA activate phospholipase D in Caco-2 cells: role of PKC-alpha
Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G993 - G1004.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Khare, M. Bissonnette, R. Wali, S. Skarosi, G. R. Boss, F. C. von Lintig, B. Scaglione-Sewell, M. D. Sitrin, and T. A. Brasitus
1,25-Dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60c-src and RhoA
Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G1005 - G1015.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. Xue, M. Lipkin, H. Newmark, and J. Wang
Influence of Dietary Calcium and Vitamin D on Diet-Induced Epithelial Cell Hyperproliferation in Mice
J Natl Cancer Inst, January 20, 1999; 91(2): 176 - 181.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J.A. Baron, M. Beach, J.S. Mandel, R.U. van Stolk, R.W. Haile, R.S. Sandler, R. Rothstein, R.W. Summers, D.C. Snover, G.J. Beck, et al.
Calcium Supplements for the Prevention of Colorectal Adenomas
N. Engl. J. Med., January 14, 1999; 340(2): 101 - 107.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
P. R. Holt, E. O. Atillasoy, J. Gilman, J. Guss, S. F. Moss, H. Newmark, K. Fan, K. Yang, and M. Lipkin
Modulation of Abnormal Colonic Epithelial Cell Proliferation and Differentiation by Low-Fat Dairy Foods: A Randomized Controlled Trial
JAMA, September 23, 1998; 280(12): 1074 - 1079.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. N. Ames and L. S. Gold
In Reply: Carcinogenic Risk Estimation
Science, May 20, 1988; 240(4855): 1045 - 1047.
[PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.