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© 1988 Oxford University Press

research-article

Ploidy distribution in experimental liver carcinogenesis in mice

Håvard E. Danielsen 1 3 4, Harald B. Steen 2, Tore Lindmo 2 3 and Albrecht Reith 1

1Department of Pathology, Laboratory for Electron Microscopy and Morphometry Montebello, 0310 Oslo 3, Norway
2Department of Biophysics, The Norwegian Radium Hospital and Institute for Cancer Research Montebello, 0310 Oslo 3, Norway
3The Norwegian Cancer Society Norway

4To whom reprint requests should be sent

There have been several reports on the distribution of DNA in premalignant and malignant liver cells after carcinogen treatment in rodents. The most striking result so far is that ploidy distributions seems to depend more on experimental protocols and less on carcinogenesis per se. The present study demonstrates that an evaluation by means of flow cytometry and stereological image analysis yields results showing similar ploidy distributions throughout the known sequence of tissue changes seen during liver cancer development. Furthermore, our results demonstrate inter-individual differences between the lesions in each of the steps in these tissue changes, (foci, nodules and hepatocarcinomas). The present study gives no reason to conclude that changes in ploidy distribution are essential in liver carcinogenesis.


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