Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Svensson, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Svensson, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 Oxford University Press

research-article

Alkylation of protein and DNA in mice treated with urethane

K. Svensson

Department of Radiobiology, Stockholm University S-106 91 Stockholm, Sweden

14C-labelled urethane in the dose interval 1–260 mg/kg was given to male CBA mice by i.p. injection. The formation of epoxyethyl carbamate, the suggested electrophilic intermediate of urethane, was studied through measurements of 2-oxoethyl adducts to the amino acids cysteine, terminal valine and histidine in protein (especially haemoglobin) and to N-7 of guanine in DNA in various tissues 9 h after treatment. The extent of binding to haemoglobin and liver DNA increased linearly with administered amount, in accordance with a complete clearance of urethane at all doses. The DNA binding varied between organs and decreased in the order liver > kidney > spleen > testis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.