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Carcinogenesis Advance Access published online on October 29, 2009
Carcinogenesis, doi:10.1093/carcin/bgp262
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Chemical Biology of Mutagenesis and DNA Repair: Cellular Responses to DNA Alkylation

Nidhi Shrivastav, Deyu Li and John M. Essigmann*

Department of Biological Engineering and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139

E-mail: jessig{at}mit.edu

The reaction of DNA damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events, and they can disrupt expression of genes. Determination of which adduct is responsible for each of these biological endpoints is difficult, but this task has been accomplished for some carcinogenic DNA damaging agents. Here, we describe the respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents.

* Address correspondence to this author.

Received August 19, 2009; revised October 20, 2009; accepted October 21, 2009.


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